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Hibernation as a model for studies on thermogenesis and its control
Experientia. Supplementum
|January 1, 1978
Summary
Mammalian hibernation involves cycles of low body temperature and arousal, where metabolic rates surge significantly. Research suggests thermogenesis control occurs at the effector level, influenced by factors like acid-base balance during hibernation.
Area of Science:
- Physiology
- Mammalian Hibernation
- Thermogenesis
Background:
- Hibernation involves cycles of hypothermia and arousal.
- High metabolic rates during arousal remain unexplained.
- Hypothalamic thermostat resets, but other regulations exist.
Purpose of the Study:
- Investigate thermogenesis control during mammalian hibernation.
- Explore effector-level regulation of metabolic rate and temperature.
- Examine the role of acid-base state in hibernation thermogenesis.
Main Methods:
- Analysis of metabolic rate during arousal.
- Assessment of enzymatic adaptations at low temperatures.
- Evaluation of hypothalamic thermostat function.
- Investigation of effector-level control mechanisms.
- Study of acid-base state changes during hibernation.
Main Results:
- Metabolic rate increases 6-8 times basal metabolic rate (BMR) during arousal, despite lower body temperature.
- Enzymatic adaptations support normal function at low temperatures.
- Evidence supports effector-level control of thermogenesis, including baseline and loop gains.
- Hibernation is characterized by a significant acidosis, linked to ventilation and acid-base state.
Conclusions:
- Thermogenesis during hibernation arousal involves complex effector-level regulation beyond hypothalamic control.
- Acid-base state, particularly acidosis, is a key factor influencing thermogenesis during hibernation.
- Further research is needed to fully elucidate the mechanisms of high thermogenetic rates during arousal.