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Complement activation in uveitis.

S Vergani, E Di Mauro, E T Davies

The British Journal of Ophthalmology

|January 1, 1986

Summary

This summary is machine-generated.

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Complement activation, indicated by elevated C3d levels, is present in most idiopathic uveitis patients, suggesting its role in inflammation. This may be triggered by immune complexes in the uvea.

Area of Science:

Ophthalmology
Immunology
Rheumatology

Background:

Uveitis is an inflammatory eye condition.
The role of the complement system in uveitis pathogenesis is not fully understood.

Purpose of the Study:

To investigate complement activation in patients with idiopathic uveitis.
To assess the correlation between complement activation and circulating immune complexes.

Main Methods:

Plasma levels of C3d, a marker of complement activation, were measured.
Circulating immune complexes containing complement components were analyzed.

Main Results:

Elevated C3d levels were detected in 11 out of 15 patients with idiopathic uveitis.
Thirteen patients had circulating immune complexes containing complement components.

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Conclusions:

Complement activation is likely involved in the pathogenesis of idiopathic uveitis.
Uveal deposition of immune complexes may trigger complement activation and inflammation.