Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer02:18

Cancer

50.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
50.7K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.9K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.9K
What is Cancer?02:12

What is Cancer?

11.5K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
11.5K
Metastasis02:30

Metastasis

5.8K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.8K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

13.2K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
13.2K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

9.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating Associations Between Cumulative Use of Chronic Liver Injury-Inducing Antiretroviral Therapy and Hepatocellular Carcinoma, By Chronic Liver Disease Status.

Journal of acquired immune deficiency syndromes (1999)·2026
Same author

Exploring Phosphatidylethanol Cutoffs for Self-Reported Unhealthy Alcohol Use: An International Multi-Site Analysis.

Alcohol, clinical & experimental research·2026
Same author

Cargo-Adaptor Cooperation Programs Retromer Coat Architecture.

bioRxiv : the preprint server for biology·2026
Same author

Increasing value in the Veterans Affairs Healthcare System (VA) with precision health: a continuing landmark collaboration with the Department of Energy.

Journal of the American Medical Informatics Association : JAMIA·2026
Same author

Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

A drug-microbiome-drug interaction impacts co-prescribed medications for Parkinson's disease.

Nature microbiology·2026
Same journal

Cluster randomized controlled trial of decision support for breast cancer chemoprevention, MiCHOICE.

Journal of the National Cancer Institute·2026
Same journal

Beyond R2: Assessing quality of trial level surrogate endpoints in colorectal cancer.

Journal of the National Cancer Institute·2026
Same journal

A novel classification of small bowel adenocarcinoma based on the hidden genome classifier: a multi-institutional study.

Journal of the National Cancer Institute·2026
Same journal

Response to Yu, Wang and Ge.

Journal of the National Cancer Institute·2026
Same journal

Re: Cardiovascular disease risk after radiotherapy and anthracycline-based chemotherapy for diffuse large B-cell lymphoma.

Journal of the National Cancer Institute·2026
Same journal

Welcome reduction of US cervical cancer rates despite state differences.

Journal of the National Cancer Institute·2026
See all related articles

Related Experiment Video

Updated: Oct 11, 2025

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

349

Cancer Microbiology.

Daniel DiMaio1,2,3,4, Brinda Emu4,5, Andrew L Goodman4,6

  • 1Department of Genetics, Yale School of Medicine, New Haven, CT, USA.

Journal of the National Cancer Institute
|December 1, 2021
PubMed
Summary
This summary is machine-generated.

Microbes significantly impact cancer, causing 15% of cases and influencing treatment. The emerging field of cancer microbiology integrates infection control and microbiome research for prevention and therapy.

More Related Videos

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
05:17

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

8.7K
Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
09:53

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

7.4K

Related Experiment Videos

Last Updated: Oct 11, 2025

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

349
Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
05:17

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

8.7K
Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
09:53

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

7.4K

Area of Science:

  • Microbiology
  • Oncology
  • Infectious Diseases

Background:

  • Microorganisms are implicated in cancer development, accounting for approximately 15% of global cancer cases, particularly in low- and middle-income countries.
  • Infectious carcinogens possess unique characteristics like transmissibility and mutability, presenting distinct challenges and opportunities for cancer control strategies.
  • Emerging research highlights the role of the human microbiome in modulating cancer formation and influencing the efficacy and toxicity of cancer therapies.

Purpose of the Study:

  • To introduce and define the emerging field of cancer microbiology.
  • To underscore the multifaceted roles of microbes in cancer, from causation to therapeutic potential.
  • To emphasize the need for integrating microbial insights into cancer research, drug development, and public health initiatives.

Main Methods:

  • This review synthesizes current knowledge on the relationship between microbes and cancer.
  • It examines the impact of infectious agents on cancer etiology and progression.
  • It explores the influence of the human microbiome on cancer development and treatment response.

Main Results:

  • Microbial infections are responsible for a significant proportion of cancers worldwide.
  • Microbes can directly cause cancer or indirectly influence its development and progression.
  • Microorganisms offer novel avenues for cancer prevention, diagnosis, and treatment, including the use of vaccines and modulation of the microbiome.

Conclusions:

  • The field of cancer microbiology represents a paradigm shift in understanding and combating cancer.
  • Integrating knowledge of microbes and cancer is crucial for advancing prevention, treatment, and public health outcomes.
  • Further research and cross-disciplinary collaboration are essential to fully harness the potential of cancer microbiology.