Expression Atlas update: gene and protein expression in multiple species
Pablo Moreno1, Silvie Fexova1, Nancy George1
1European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Genome Campus, Hinxton, UK.
Nucleic Acids Research
|December 1, 2021
Summary
The EMBL-EBI Expression Atlas provides gene and protein expression data across tissues, conditions, and species. This resource aids researchers in understanding gene function and regulation in various biological contexts.
Area of Science:
- Genomics
- Bioinformatics
- Molecular Biology
Background:
- Researchers need comprehensive data on gene and protein expression across diverse biological contexts.
- Existing resources may lack standardized analysis or broad species coverage.
Purpose of the Study:
- To present the EMBL-EBI Expression Atlas, a curated knowledge base for gene and protein expression data.
- To provide researchers with a tool to explore expression patterns in various tissues, developmental stages, and conditions.
Main Methods:
- Aggregating and curating data from over 4500 expression studies across more than 65 species.
- Re-analyzing data using standardized pipelines with open-source tools and ontology-based metadata annotation.
- Dividing the resource into Bulk Expression Atlas (microarray, bulk RNA-Seq, proteomics) and Single Cell Expression Atlas (scRNA-Seq).
Main Results:
- Expression Atlas offers freely accessible, visualized expression data for genes and proteins.
- Data covers differential and baseline expression studies under various experimental conditions.
- The resource supports the reproduction of original experimental conclusions.
Conclusions:
- The EMBL-EBI Expression Atlas is a continuously developed, valuable resource for exploring gene and protein expression.
- It empowers researchers to investigate biological questions related to expression patterns and regulation.
- The Atlas facilitates biological discovery through standardized, high-quality expression data analysis.
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