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Related Concept Videos

Antidotes01:17

Antidotes

796
Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
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Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

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Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by...
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Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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Adrenergic Agonists: Direct-Acting Agents01:30

Adrenergic Agonists: Direct-Acting Agents

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Drugs that mimic the action of endogenous catecholamines like noradrenaline and adrenaline are called adrenergic agonists or sympathomimetics. Based on their mechanism of action, sympathomimetics can be classified as direct-, indirect-, or mixed-acting sympathomimetics. Direct-acting adrenergic agonists activate adrenoceptors without affecting presynaptic neurons, making them independent of neuronal catecholamine-depleting agents like reserpine and guanethidine.
These agents can be classified...
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Related Experiment Video

Updated: Oct 11, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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[Senolytics against Covid-19?]

Bertrand Jordan1

  • 1ADÉS (Anthropologie bioculturelle, droit, éthique et santé) UMR CNRS 7268, Aix Marseille université, Établissement français du sang. CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France.

Medecine Sciences : M/S
|December 1, 2021
PubMed
Summary
This summary is machine-generated.

Senolytic compounds clear aging cells, improving health and reversing aging effects in mice. This approach also protects aged mice from viral infections, with ongoing clinical trials for COVID-19 patients.

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Area of Science:

  • Gerontology
  • Immunology
  • Virology

Background:

  • Senescent cells accumulate with age, contributing to age-related diseases and frailty.
  • Senolytic compounds selectively eliminate senescent cells, demonstrating therapeutic potential in preclinical models.
  • A novel microbial exposure system effectively models coronavirus infection in aged mice.

Discussion:

  • Eliminating senescent cells significantly enhances the healthspan of aged mice.
  • This senolytic strategy confers substantial protection against severe outcomes of viral infections in aged populations.
  • The findings highlight a potential therapeutic avenue for age-related diseases and infectious diseases.

Key Insights:

  • Senolytic therapy can reverse some aging phenotypes and improve overall health in aged mice.
  • Targeting senescent cells provides protection against viral infections, including those mimicking coronavirus.
  • Preclinical success strongly supports the translation of senolytics into human clinical applications.

Outlook:

  • Ongoing Phase II clinical trials are evaluating senolytics in COVID-19 patients.
  • Further research will explore senolytics for preventing and treating various age-related conditions and infectious diseases.
  • Senolytics represent a promising frontier in aging research and therapeutic interventions.