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Updated: Oct 11, 2025

Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces

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Published on: September 9, 2022

Acoustofluidic dynamic interfacial tensiometry.

Umar Farooq¹, Yuanting Liu², Pengqi Li¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen 518055, China.

The Journal of the Acoustical Society of America

|December 2, 2021

Summary

A new surface acoustic wave (SAW) technique accurately measures fluid interfacial tension (IFT) in microscale volumes. This method offers a precise tool for diagnosing blood-related diseases by analyzing droplet shape changes.

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Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

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Published on: July 22, 2015

Area of Science:

Physical Chemistry
Biomedical Engineering
Materials Science

Background:

Interfacial tension (IFT) is crucial in various scientific and industrial applications.
Measuring IFT in ultralow fluid volumes presents significant challenges.
Existing methods lack precision and scalability for microscale applications.

Purpose of the Study:

To introduce a novel surface acoustic wave (SAW) based tensiometry method for microscale fluid volumes.
To enable accurate IFT measurements at the micro-liter scale.
To provide a diagnostic tool for blood-related diseases.

Main Methods:

Developed a sessile drop tensiometry technique utilizing surface acoustic waves (SAWs).
Acquired droplet silhouettes and applied iterative fitting with Taylor's deformation equation.
Analyzed microfluid streaming velocity changes induced by acoustic waves to determine IFT.

Main Results:

The SAW-based tensiometry method accurately measures IFT in microscale liquid volumes (up to 1 μL).
Achieved a high degree of accuracy with an error margin of ±5% at 25°C.
Demonstrated effectiveness in screening blood plasma for high leptin levels.

Conclusions:

The proposed SAW tensiometry offers a precise and efficient method for microscale IFT measurement.
This technique provides a valuable solution for pre-diagnosis of blood-related diseases.
The method overcomes limitations of previous techniques for ultralow volume IFT analysis.