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Related Experiment Videos

Vasoconstriction: a new activity for platelet-derived growth factor.

B C Berk, R W Alexander, T A Brock

    Science (New York, N.Y.)
    |April 4, 1986
    PubMed
    Summary

    Platelet-derived growth factor (PDGF) significantly contracts rat aortic strips and increases intracellular calcium. This suggests PDGF contributes to the altered blood vessel reactivity seen in atherosclerosis.

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    Area of Science:

    • Cardiovascular Biology
    • Vascular Physiology
    • Atherosclerosis Research

    Background:

    • Platelet-derived growth factor (PDGF) is a known mitogen for vascular smooth muscle cells.
    • PDGF is implicated in the development of atherosclerosis.
    • Altered vasoreactivity is a characteristic of atherosclerotic vessels.

    Purpose of the Study:

    • To investigate the role of PDGF in the altered vasoreactivity of atherosclerotic vessels.
    • To examine the effects of PDGF on vascular smooth muscle contractility.
    • To determine if PDGF influences intracellular calcium levels in vascular cells.

    Main Methods:

    • Experiments were conducted using rat aortic strips to assess contractility.
    • Concentration-dependent effects of PDGF on aortic strips were measured.

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  • Cytosolic free calcium concentrations in cultured rat aortic smooth muscle cells were analyzed.

    • Main Results:

    • PDGF induced a concentration-dependent contraction in rat aortic strips.
    • PDGF demonstrated greater potency as a vasoconstrictor than angiotensin II on a molar basis.
    • PDGF administration led to an increase in cytosolic free calcium in cultured aortic smooth muscle cells.

    Conclusions:

    • PDGF exhibits potent vasoconstrictive activity.
    • PDGF's ability to increase intracellular calcium suggests a novel biological function.
    • These findings indicate PDGF may contribute to the enhanced vasoreactivity observed in atherosclerotic vessels.