Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in T-lymphocyte subsets after elective surgery.

S Madsbad, K Buschard, O Siemssen

    Acta Chirurgica Scandinavica
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
    Same author

    The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
    Same author

    Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB.

    Obesity science & practice·2017
    Same author

    Nutrient re-routing and altered gut-islet cell crosstalk may explain early relief of severe postprandial hypoglycaemia after reversal of Roux-en-Y gastric bypass.

    Diabetic medicine : a journal of the British Diabetic Association·2017
    Same author

    Increased glucose-stimulated FGF21 response to oral glucose in obese nondiabetic subjects after Roux-en-Y gastric bypass.

    Clinical endocrinology·2016
    Same author

    Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery.

    International journal of obesity (2005)·2016
    Same journal

    Uretero-intestinal implantation according to Coffey.

    Acta chirurgica Scandinavica·2010
    Same journal

    Closure of the bronchus in pneumonectomy and lobectomy.

    Acta chirurgica Scandinavica·2010
    Same journal

    Tables for calculation of exact measurements of radiographed objects.

    Acta chirurgica Scandinavica·2010
    Same journal

    Treatment of the congenital flat-foot.

    Acta chirurgica Scandinavica·2010
    Same journal

    On the practical importance of the clinical determination of the basal metabolic rate in thyrotoxicosis.

    Acta chirurgica Scandinavica·2010
    Same journal

    Splanchnectomy by megacolon congenitum.

    Acta chirurgica Scandinavica·2010
    See all related articles

    Post-surgery, the ratio of helper to suppressor T-cells (OKT 4/8) significantly decreased in patients. This change in immune cell balance may increase susceptibility to bacterial infections after surgery.

    Area of Science:

    • Immunology
    • Surgical Oncology

    Background:

    • Post-surgical patients often exhibit increased susceptibility to infections.
    • T-cell subsets play a crucial role in immune regulation.

    Purpose of the Study:

    • To investigate the changes in T-cell subsets (helper and suppressor/cytotoxic) after elective surgical procedures.
    • To evaluate the postoperative T-cell ratio (OKT 4/8) and its potential implications for immune function.

    Main Methods:

    • Quantification of helper T-cells (OKT 4) and suppressor/cytotoxic T-cells (OKT 8) using monoclonal antibodies (OKT).
    • Measurements were taken preoperatively and on postoperative days 2 and 7 in seven patients undergoing cholecystectomy or vagotomy.

    Main Results:

    • Total T-cells (OKT 3) and helper T-cells (OKT 4) showed no significant changes postoperatively.

    Related Experiment Videos

  • A significant increase in suppressor/cytotoxic T-cells (OKT 8) was observed on postoperative days 2 and 7.
  • The OKT 4/8 ratio significantly decreased on postoperative days 2 and 7 compared to preoperative levels.

    • Conclusions:

    • Elective surgery leads to a significant decrease in the helper/suppressor T-cell ratio.
    • This altered immune balance may contribute to the increased risk of bacterial infections in the postoperative period.