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Related Concept Videos

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Stem Cell-Based Therapies: What Interventional Radiologists Need to Know.

Hyeon Yu1,2, Clayton W Commander1, Joseph M Stavas3

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Seminars in Interventional Radiology
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Summary
This summary is machine-generated.

Stem cell therapies offer new hope for treating diseases. Interventional radiologists can enhance treatment success by precisely delivering stem cells to target tissues using minimally invasive methods.

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Developmental Biology

Background:

  • Stem cells are fundamental to development and regeneration due to self-renewal and differentiation.
  • Stem cell therapies are being developed for untreatable or difficult-to-treat diseases.
  • Effective stem cell therapy relies on optimal delivery to target tissues.

Purpose of the Study:

  • To review stem cell types, sources, and current clinical applications.
  • To discuss the role of interventional radiology in stem cell therapy delivery.
  • To explore regulatory considerations and logistics for stem cell therapies.

Main Methods:

  • Literature review of stem cell biology and therapy.
  • Analysis of image-guided, minimally invasive stem cell delivery techniques.
  • Examination of interventional radiology's potential contribution.

Main Results:

  • Stem cell therapies hold promise for various diseases.
  • Image-guided locoregional injections can improve stem cell delivery efficiency.
  • Interventional radiology offers expertise in minimally invasive procedures for targeted delivery.

Conclusions:

  • Optimizing stem cell delivery is crucial for therapeutic efficacy.
  • Interventional radiology can play a significant role in advancing stem cell therapies.
  • Further research into regulatory aspects and logistics is needed.