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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

163
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
163
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

95
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
95
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

63
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
63
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

85
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
85
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

65
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
65
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

475
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
475

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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Cancer-Associated Atherothrombosis: The Challenge.

Jochanan E Naschitz1,2

  • 1The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|December 2, 2021
PubMed
Summary
This summary is machine-generated.

Cancer is linked to arterial thromboembolism (ATE), a paraneoplastic syndrome. Early detection and intervention are crucial for managing ATE in cancer patients to improve outcomes.

Keywords:
cancercoronary artery diseaseparaneoplasticperipheral arterial diseasestrokethrombosis

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Area of Science:

  • Cardiovascular Medicine
  • Oncology
  • Thrombosis Research

Background:

  • Venous thrombosis is a known paraneoplastic syndrome associated with malignancy.
  • Arterial thromboembolism (ATE) is increasingly recognized as a paraneoplastic syndrome in cancer patients.
  • Cancer patients with ATE face higher mortality risks compared to non-cancer patients.

Purpose of the Study:

  • To review the epidemiology, clinical presentation, and management of cancer-associated ATE.
  • To highlight the increased incidence of ATE preceding cancer diagnosis.
  • To discuss prevention strategies and treatment outcomes for ATE in the context of cancer.

Main Methods:

  • Systematic review of matched cohort studies, systematic reviews, and observational studies.
  • Analysis of incidence, morbidity, and mortality data for cancer-associated ATE.
  • Evaluation of current prevention and treatment approaches.

Main Results:

  • An increased incidence of ATE, including acute coronary events and ischemic stroke, occurs in the 6 months preceding cancer diagnosis.
  • Cancer patients with ATE exhibit worse in-hospital and long-term mortality.
  • Efficacy of statins and antiplatelet agents for ATE prevention in cancer patients is not yet established.
  • Revascularization outcomes for cancer-associated ATE are poorer than in non-cancer patients.

Conclusions:

  • Cancer is a significant risk factor for ATE, necessitating proactive identification and management.
  • Multidisciplinary care involving oncologists, vascular specialists, and palliative medicine is essential for optimal decision-making.
  • Further research is needed to establish effective prophylactic and therapeutic strategies for cancer-associated ATE.