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Relationship between Mean Platelet Volume and Critical Limb Ischemia in Diabetes Mellitus Patients

Muhammad Berian Rachmanadi1, Muhamad Taufik Ismail2, Vita Yanti Anggraeni2

  • 1Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|December 2, 2021
PubMed

Insights

Mean platelet volume (MPV) may predict critical limb ischemia (CLI) in diabetes patients. Lower MPV levels were significantly associated with increased CLI incidence, suggesting MPV

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Hematology

Background:

  • Diabetes mellitus prevalence is rising globally.
  • Critical limb ischemia (CLI) is a severe diabetes complication.
  • CLI necessitates amputation if untreated, carrying high mortality.

Purpose of the Study:

  • To investigate the association between Mean Platelet Volume (MPV) and CLI incidence in diabetes mellitus patients.
  • To determine if MPV can serve as a predictive marker for CLI in this population.

Main Methods:

  • A case-control study utilizing data from the Dr. Sardjito Hospital vascular registry (January 2016 - December 2016).
  • Bivariate and multivariate analyses were employed to assess the relationship between MPV and CLI.
  • Potential confounding factors including sex, age, obesity, dyslipidemia, and antiplatelet agent use were evaluated.

Main Results:

  • A significant association was found between MPV and CLI incidence in diabetes mellitus patients (p < 0.05).
  • Diabetes patients with MPV ≥ 9.8 fL demonstrated a protective effect against CLI (OR = 0.366, aOR = 0.288).
  • Low MPV was significantly linked to a higher incidence of CLI in diabetes mellitus patients.

Conclusions:

  • Mean platelet volume (MPV) is significantly associated with critical limb ischemia (CLI) in diabetes mellitus patients.
  • Lower MPV levels may indicate an increased risk of developing CLI.
  • MPV could potentially be a valuable biomarker for predicting CLI risk in diabetic individuals.

Keywords:
case–controlcritical limb ischemiadiabetes mellitusmean platelet volume

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