COVID-19 Legacy.

Area of Science:

• Infectious Diseases
• Public Health
• Virology

Background:

• Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, resulted in a global pandemic.
• The acute phase presents with diverse symptoms, including respiratory failure, neurological events, and dermatological manifestations.
• Long-term sequelae (long COVID) and unpredictable recovery trajectories affect survivors, even those with initially mild illness.

Purpose of the Study:

• To highlight the need for comprehensive understanding of post-acute COVID-19 manifestations.
• To emphasize the ongoing uncertainty in determining prognoses for COVID-19 survivors.
• To advocate for the examination of patient databases to inform long-term care.

Main Methods:

• Review of existing literature on COVID-19 acute and prolonged symptoms.
• Identification of key areas requiring further investigation, such as post-acute dyspnea, anosmia, and multisystem inflammatory response syndrome.
• Proposal for the analysis of patient databases by multidisciplinary teams.

Main Results:

• COVID-19 can lead to a wide spectrum of acute symptoms and chronic sequelae.
• Long-term complications can affect various organ systems and persist even after mild initial infections.
• Prognosis determination for long COVID remains challenging due to the evolving understanding of the disease.

Conclusions:

• Continued research and analysis of patient data are essential to understand the long-term impact of COVID-19.
• Multidisciplinary approaches are necessary to assess and manage the diverse complications of long COVID.
• Improved understanding will guide the development of targeted treatments and improve patient outcomes.