Related Experiment Video
Updated: Oct 11, 2025
04:33
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
867
Correlation between S100B and severity of depression in MDD: A meta-analysis
Umit Tural1, Molly Kennedy Irvin1, Dan Vlad Iosifescu1,2
1Clinical Research Division, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Summary
This meta-analysis found a significant positive correlation between S100B protein levels and major depressive disorder (MDD) severity. Increased S100B may indicate worsening depression symptoms in MDD patients.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Elevated S100B protein levels, found in glial cells, are observed in major depressive disorder (MDD).
- Previous research on the correlation between S100B levels and MDD severity has yielded conflicting results.
Approach:
- A systematic review and meta-analysis was conducted to evaluate the correlation between S100B levels and depression severity in MDD patients.
- Pearson correlation coefficients from 16 studies (658 patients) were pooled using a random-effects model.
- Meta-regression analysis explored potential modifiers of the observed effect size, such as age of onset and participant demographics.
Key Points:
- A significant positive correlation was found between serum S100B levels and MDD severity (r=0.204, p=0.022).
- No publication bias was detected in the included studies.
- Onset age of MDD and the proportion of female participants were identified as significant modifiers of the S100B-severity correlation.
Conclusions:
- This meta-analysis supports the link between increased S100B levels and the severity of MDD.
- Further research is recommended to elucidate the specific biological mechanisms connecting S100B and MDD.
Related Concept Videos
01:27Depressive Disorders: Etiology
182
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
182
01:27Depressive Disorders: MDD and Dysthymia
236
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
236
01:18Depression: Overview
424
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
424
01:21G-protein Coupled Receptors
124.4K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
124.4K
01:03Long-term Depression
2.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.7K