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Cancer diagnosis and analysis devices based on multimolecular crowding.

Daisuke Onoshima1, Yoshinobu Baba1,2,3

  • 1Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. onoshima-d@nanobio.nagoya-u.ac.jp.

Chemical Communications (Cambridge, England)
|December 2, 2021
PubMed
Summary

Multimolecular crowding around cancer cells enables new diagnostic devices. Analyzing circulating tumor cells and exosomes aids in early cancer detection and treatment strategies.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Multimolecular crowding around cancer cells influences malignancy.
  • Circulating tumor cells and extracellular vesicles carry cancer biomarkers.
  • Intercellular communication is key to cancer progression.

Purpose of the Study:

  • To explore the potential of multimolecular crowding in cancer diagnosis and analysis.
  • To highlight the role of nanobiodevice engineering in disease detection.
  • To identify novel targets for less invasive cancer testing and treatment.

Main Methods:

  • Analysis of intercellular communication related to cancer malignancy.
  • Separation and analysis of circulating cancer cells from blood.
  • Raman scattering for label-free cancer cell detection.
  • Exosome analysis for cancer trait evaluation.

Main Results:

  • Multimolecular crowding offers new avenues for cancer diagnostics.
  • Circulating biomarkers can be leveraged for ultra-early cancer diagnosis.
  • Nanobiodevice engineering shows promise for disease analysis.

Conclusions:

  • Nanobiodevice engineering utilizing multimolecular crowding can advance cancer diagnosis and analysis.
  • This approach holds potential for developing novel anti-cancer drugs and early detection devices.
  • The application of these technologies may extend to diagnosing and analyzing various other diseases.