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Updated: Oct 11, 2025
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Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
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Cancer diagnosis and analysis devices based on multimolecular crowding
Daisuke Onoshima1, Yoshinobu Baba1,2,3
1Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. onoshima-d@nanobio.nagoya-u.ac.jp.
Chemical Communications (Cambridge, England)
|December 2, 2021
Summary
Multimolecular crowding around cancer cells enables new diagnostic devices. Analyzing circulating tumor cells and exosomes aids in early cancer detection and treatment strategies.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Research
Background:
- Multimolecular crowding around cancer cells influences malignancy.
- Circulating tumor cells and extracellular vesicles carry cancer biomarkers.
- Intercellular communication is key to cancer progression.
Purpose of the Study:
- To explore the potential of multimolecular crowding in cancer diagnosis and analysis.
- To highlight the role of nanobiodevice engineering in disease detection.
- To identify novel targets for less invasive cancer testing and treatment.
Main Methods:
- Analysis of intercellular communication related to cancer malignancy.
- Separation and analysis of circulating cancer cells from blood.
- Raman scattering for label-free cancer cell detection.
- Exosome analysis for cancer trait evaluation.
Main Results:
- Multimolecular crowding offers new avenues for cancer diagnostics.
- Circulating biomarkers can be leveraged for ultra-early cancer diagnosis.
- Nanobiodevice engineering shows promise for disease analysis.
Conclusions:
- Nanobiodevice engineering utilizing multimolecular crowding can advance cancer diagnosis and analysis.
- This approach holds potential for developing novel anti-cancer drugs and early detection devices.
- The application of these technologies may extend to diagnosing and analyzing various other diseases.
