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QTc interval prolongation in the patients with primary biliary cholangitis
Zihao Wang1, Rongkai Qian1, Yanhua Wang2
1Xi'an Jiaotong University, Xi'an, China.
Summary
QT interval prolongation is common in primary biliary cholangitis (PBC) patients, particularly those with advanced liver disease. Age and Child-Pugh classification are key risk factors for this cardiac issue in PBC.
Area of Science:
- Cardiology
- Hepatology
- Clinical Research
Background:
- QT interval prolongation is linked to fatal arrhythmias and cardiac death.
- Limited data exist on QT interval prolongation in primary biliary cholangitis (PBC).
- Understanding QTc prolongation in PBC is crucial for patient risk stratification.
Purpose of the Study:
- To determine the prevalence of corrected QT (QTc) interval prolongation in PBC patients.
- To identify risk factors associated with QTc interval prolongation in this cohort.
Main Methods:
- Retrospective study of 189 PBC patients from January 2016 to December 2020.
- Surveyed the rate of QTc interval prolongation.
- Employed univariate and multivariate analyses to identify associated risk factors.
Main Results:
- 24.3% of PBC patients exhibited QTc interval prolongation.
- Univariate analysis indicated age, Child-Pugh class, creatinine, INR, and PLT were associated.
- Multivariate analysis identified age (p=.028) and Child-Pugh classification (p=.035) as significant risk factors.
Conclusions:
- QTc interval prolongation is frequent in PBC patients, especially those with decompensated cirrhosis.
- The highest risk (64.3%) was observed in patients over 62.5 years old with Child-Pugh C classification.
- Age and advanced liver disease severity are critical factors for QTc prolongation in PBC.
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