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Updated: Oct 11, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

[Partial breast irradiation].

Sophie C J Bosma^1,2, Paula H M Elkhuizen¹

¹Antoni van Leeuwenhoek, afd. Radiotherapie, Amsterdam.

Nederlands Tijdschrift Voor Geneeskunde

|December 2, 2021

Summary

This summary is machine-generated.

Partial breast irradiation (PBI) offers a reduced toxicity alternative to whole breast radiotherapy for early-stage breast cancer patients with low recurrence risk. This targeted approach maintains low local recurrence rates while potentially improving cosmetic outcomes.

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Area of Science:

Oncology
Radiation Oncology

Background:

Breast-conserving therapy (BCT), including surgery and whole breast radiotherapy (WBI), is standard for early-stage breast cancer.
Partial breast irradiation (PBI) is an alternative for low-risk patients, targeting the tumor bed to minimize toxicity.

Purpose of the Study:

To evaluate PBI as an alternative to WBI for early-stage breast cancer.
To assess the efficacy and toxicity of PBI in reducing local recurrence rates and improving outcomes.

Main Methods:

PBI involves irradiating only the tumor bed and surrounding area.
Delivery methods include brachytherapy, intraoperative radiation therapy, and external beam radiation therapy (EBRT).
Studies compare PBI outcomes to WBI, focusing on toxicity and local recurrence.

Main Results:

PBI is associated with reduced toxicity compared to WBI.
Similar or improved cosmetic outcomes have been observed with PBI.
PBI maintains an acceptable low local recurrence rate.

Conclusions:

PBI is a viable alternative to WBI for select early-stage breast cancer patients.
Reduced radiation volume in PBI leads to less toxicity and potentially better cosmesis.
Further research supports PBI's role in optimizing breast cancer treatment.