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Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

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Published on: July 25, 2011

Cutaneous SCC with orbital invasion: case series.

M Nägeli¹, J Mangana¹, K Chaloupka²

¹Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Journal of the European Academy of Dermatology and Venereology : JEADV

|December 2, 2021

Summary

Cutaneous squamous cell carcinoma (cSCC) invading the orbit is challenging to treat. Immune-checkpoint inhibitors showed variable responses in four orbital invasion cases, highlighting the need for interdisciplinary care.

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Area of Science:

Ophthalmology
Dermatology
Oncology

Background:

Cutaneous squamous cell carcinoma (cSCC) is a common orbital tumor.
Basal cell carcinoma (BCC) is a common eyelid tumor.
Diagnostic delays for orbital tumors can worsen outcomes.

Observation:

This study reviewed four cases of cSCC with orbital invasion.
Patients were treated with immune-checkpoint inhibitors.
Treatment responses were variable.

Findings:

cSCC is the most frequent secondary orbital tumor.
Orbital invasion by cSCC presents therapeutic challenges.
Immune-checkpoint inhibitors offer a potential treatment avenue with unpredictable efficacy.

Implications:

Interdisciplinary tumor board discussion is crucial for managing orbital cSCC.
Further research is needed to optimize immune-checkpoint inhibitor therapy for orbital invasion.
Early diagnosis and treatment are vital to minimize complications.