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Generation of Human Microglia to Combine Them with Retinal Organoids for Improved Disease Modeling
Published on: July 26, 2024
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The gut microbiota in retinal diseases.
Marie-Agnès Bringer1, Pierre-Henry Gabrielle2, Alain M Bron2
1Eye and Nutrition Research Group, Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, F-21000, Dijon, France.
Experimental Eye Research
|December 2, 2021
Summary
The gut microbiota, a complex community of microorganisms, impacts overall health. Imbalances (dysbiosis) are linked to diseases, including potential roles in retinopathies via the microbiota-retina axis.
Area of Science:
- Microbiology
- Gastroenterology
- Ophthalmology
Background:
- The gut microbiota is a dynamic ecosystem crucial for host homeostasis.
- Dysbiosis, an imbalance in microbial communities, is linked to various diseases.
- Emerging research highlights the microbiota-retina axis.
Purpose of the Study:
- To review current knowledge on the microbiota-retina axis.
- To explore the role of gut dysbiosis in retinopathies.
- To discuss microbiota-targeting strategies for retinal diseases.
Main Methods:
- Literature review of scientific advances.
- Analysis of the interplay between host and environmental factors on gut microbiota.
- Examination of physiological processes regulated by the gut microbiota.
Main Results:
- The gut microbiota influences health and disease, including distant organs like the brain.
- Gut dysbiosis is associated with inflammatory, metabolic, and CNS disorders.
- The microbiota-retina axis is an emerging concept in understanding retinopathies.
Conclusions:
- Disturbances in the microbiota-retina axis may contribute to retinopathies.
- Microbiota-targeting strategies show potential for preventing and treating retinopathies.
