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Too complex to fail? Targeting fatty acid metabolism for cancer therapy
Rimsha Munir1, Jan Lisec2, Johannes V Swinnen3
1Cancer Biology Lab, Institute of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan; Hormone Lab Lahore, Pakistan.
Abstract:
Given the central role of fatty acids in cancer pathophysiology, the exploitation of fatty acid metabolism as a potential antineoplastic therapy has gained much attention. Several natural and synthetic compounds targeting fatty acid metabolism were hitherto identified, and their effectiveness against cancer cell proliferation and survival was determined. This review will discuss the most clinically viable inhibitors or drugs targeting various proteins or enzymes mapped on nine interconnected fatty acid metabolism-related processes. We will discuss the general significance of each of these processes and the effects of their inhibition on cancer cell progression. Moreover, their mechanisms of action, limitations, and future perspectives will be assessed.
Insights
Targeting fatty acid metabolism offers a promising antineoplastic therapy. This review explores clinically viable drugs inhibiting key proteins and enzymes in nine interconnected fatty acid metabolic processes for cancer treatment.
Area of Science:
- Biochemistry
- Oncology
- Pharmacology
Background:
- Fatty acids play a crucial role in cancer pathophysiology.
- Altering fatty acid metabolism is a recognized strategy for cancer therapy.
- Numerous compounds targeting fatty acid metabolism have been identified.
Purpose of the Study:
- To review clinically viable inhibitors and drugs targeting fatty acid metabolism.
- To discuss nine interconnected fatty acid metabolism processes relevant to cancer.
- To assess the effects of inhibiting these processes on cancer progression.
Main Methods:
- Literature review of natural and synthetic compounds.
- Analysis of proteins and enzymes involved in fatty acid metabolism.
- Evaluation of drug effectiveness against cancer cell proliferation and survival.
Main Results:
- Identification of clinically viable inhibitors and drugs.
- Detailed discussion of nine key fatty acid metabolism pathways.
- Assessment of inhibition effects on cancer cell progression, mechanisms, and limitations.
Conclusions:
- Fatty acid metabolism is a viable target for antineoplastic therapy.
- Inhibitors targeting these pathways show potential in cancer treatment.
- Further research into mechanisms, limitations, and future perspectives is warranted.
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