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A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft
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Trends in cardiovascular medicine: Update on cardiac transplantation

Amanda C Coniglio1, Benjamin S Bryner2, Adam D Devore1

  • 1Department of Medicine, Duke University School of Medicine, Durham, NC, United States.

Trends in Cardiovascular Medicine
|December 2, 2021
PubMed

Insights

Cardiac transplantation offers a cure for advanced heart failure, a condition affecting over 250,000 Americans. Recent innovations have expanded the donor pool, increasing transplant availability for patients.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Immunology

Background:

  • Advanced heart failure impacts over 250,000 individuals in the US, carrying significant morbidity and mortality risks.
  • Cardiac transplantation is a curative option, historically constrained by limited donor organ availability.

Purpose of the Study:

  • To review recent advancements in cardiac transplantation.
  • To highlight innovations expanding donor availability and improving patient access to heart transplants.

Main Methods:

  • Review of recent literature and clinical updates in cardiac transplantation.
  • Analysis of changes in organ allocation systems.
  • Examination of novel donor selection, procurement, and desensitization protocols.

Main Results:

  • Wider donor pool due to revised allocation systems.
  • Improved donor selection and procurement strategies.
  • Advancements in desensitization protocols enhancing graft acceptance.

Conclusions:

  • Recent innovations are significantly increasing the availability of cardiac transplantation.
  • These advances offer improved outcomes and access for patients with advanced heart failure.

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