Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Predictive value of BMD for hip and other fractures: a meta-analysis to update FRAX.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Correction: A meta-analysis of previous falls and subsequent fracture risk in cohort studies.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Predictive value of BMD for hip and other fractures: a meta-analysis to update FRAX.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

A meta-analysis of smoking and fracture risk to update the FRAX® tool.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Family history of fracture and fracture risk: a meta-analysis to update the FRAX® risk assessment tool.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2025
Same author

Body mass index and subsequent fracture risk: a meta-analysis to update FRAX.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025

Related Experiment Video

Updated: Oct 11, 2025

Author Spotlight: Enhancing Accuracy and Reproducibility in Whole Bone Bending Tests
04:20

Author Spotlight: Enhancing Accuracy and Reproducibility in Whole Bone Bending Tests

Published on: September 1, 2023

1.0K

Associations between parameters of peripheral quantitative computed tomography and bone material strength index.

Kara L Holloway-Kew1, Pamela Rufus-Membere1, Kara B Anderson1

  • 1Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, Australia.

Bone
|December 2, 2021
PubMed
Summary

This study found weak associations between bone material strength index (BMSi) and bone parameters measured by peripheral quantitative computed tomography (pQCT). These associations were independent of several confounding factors, suggesting limited correlation between these bone health metrics.

Keywords:
Bone material strength indexImpact microindentationMenPeripheral quantitative computed tomography

More Related Videos

Proximal Cadaveric Femur Preparation for Fracture Strength Testing and Quantitative CT-based Finite Element Analysis
08:04

Proximal Cadaveric Femur Preparation for Fracture Strength Testing and Quantitative CT-based Finite Element Analysis

Published on: March 11, 2017

9.5K
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.0K

Related Experiment Videos

Last Updated: Oct 11, 2025

Author Spotlight: Enhancing Accuracy and Reproducibility in Whole Bone Bending Tests
04:20

Author Spotlight: Enhancing Accuracy and Reproducibility in Whole Bone Bending Tests

Published on: September 1, 2023

1.0K
Proximal Cadaveric Femur Preparation for Fracture Strength Testing and Quantitative CT-based Finite Element Analysis
08:04

Proximal Cadaveric Femur Preparation for Fracture Strength Testing and Quantitative CT-based Finite Element Analysis

Published on: March 11, 2017

9.5K
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.0K

Area of Science:

  • Orthopedics
  • Bone Physiology
  • Medical Imaging

Background:

  • Bone material strength index (BMSi) is a key indicator of bone health.
  • In vivo measurement of BMSi is performed using impact microindentation (IMI).
  • The relationship between BMSi and other bone assessment methods requires further clarification.

Purpose of the Study:

  • To investigate the association between BMSi and bone parameters obtained via peripheral quantitative computed tomography (pQCT).
  • To determine if pQCT-derived bone measures correlate with in vivo BMSi.
  • To explore potential independent associations after adjusting for confounders.

Main Methods:

  • A cohort of 373 men aged 34-96 years from the Geelong Osteoporosis Study was analyzed.
  • BMSi was measured using an OsteoProbe.
  • pQCT was utilized to assess bone parameters at the radius and tibia at 4% and 66% of length.
  • Spearman's correlation and multivariable regression analyses were employed.

Main Results:

  • Weak positive associations were observed between BMSi and total bone density at the radius (4%) and tibia (4%).
  • Cortical bone density at the tibia (4%) also showed a weak association with BMSi.
  • These associations remained significant and independent of weight, height, and glucocorticoid use.

Conclusions:

  • Limited, weak associations exist between specific pQCT-derived bone parameters and BMSi.
  • The findings suggest that BMSi and pQCT-derived measures capture distinct aspects of bone health.
  • Further research is needed to fully elucidate the interplay between different bone assessment techniques.