Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Steel Manufacturing01:26

Steel Manufacturing

881
Steel manufacturing is a multi-stage process that begins by smelting iron ore into cast iron in a blast furnace. This initial stage involves layering iron ore with coke, a type of fuel, and crushed limestone within the furnace. The coke is ignited with a high volume of air, leading to the creation of carbon monoxide, which acts to reduce the iron ore to pure iron.
During this smelting process, limestone plays a crucial role by forming slag. Slag captures impurities within the molten iron, such...
881

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ABCG2/BCRP transport mechanism revealed through kinetically excited targeted molecular dynamics simulations.

Computational and structural biotechnology journal·2022
Same author

Management of sirolimus treatment for tumours associated with Kasabach-Merritt phenomenon.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Voretigene Neparvovec challenges in clinical practice.

Journal francais d'ophtalmologie·2021
Same author

[Implementation of a new gene therapy in ophthalmology: Regulatory and organizational issues].

Journal francais d'ophtalmologie·2021
Same author

Preliminary dosimetric analysis of DOTA-folate radiopharmaceutical radiolabelled with <sup>47</sup>Sc produced through <sup>nat</sup>V(p,x)<sup>47</sup>Sc cyclotron irradiation.

Physics in medicine and biology·2021
Same author

Lithiation Mechanism in High-Entropy Oxides as Anode Materials for Li-Ion Batteries: An Operando XAS Study.

ACS applied materials & interfaces·2020

Related Experiment Video

Updated: Oct 11, 2025

Spark Plasma Sintering Apparatus Used for the Formation of Strontium Titanate Bicrystals
11:17

Spark Plasma Sintering Apparatus Used for the Formation of Strontium Titanate Bicrystals

Published on: February 9, 2017

10.0K

Target manufacturing by Spark Plasma Sintering for efficient 89Zr production.

S Cisternino1, E Cazzola2, H Skliarova3

  • 1Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro (PD), Italy; Dipartimento di Ingegneria Industriale, Università di Padova, Padova, PD, Italy.

Nuclear Medicine and Biology
|December 2, 2021
PubMed
Summary

Spark Plasma Sintering (SPS) is a novel method for creating yttrium targets to produce zirconium-89 (89Zr) for PET imaging. This technique offers efficient 89Zr production comparable to traditional methods.

Keywords:
CyclotronRadionuclide productionSolid targetSpark plasma sinteringZirconium-89

More Related Videos

Fused Filament Fabrication FFF of Metal-Ceramic Components
08:43

Fused Filament Fabrication FFF of Metal-Ceramic Components

Published on: January 11, 2019

17.5K
Bulk and Thin Film Synthesis of Compositionally Variant Entropy-stabilized Oxides
09:41

Bulk and Thin Film Synthesis of Compositionally Variant Entropy-stabilized Oxides

Published on: May 29, 2018

9.7K

Related Experiment Videos

Last Updated: Oct 11, 2025

Spark Plasma Sintering Apparatus Used for the Formation of Strontium Titanate Bicrystals
11:17

Spark Plasma Sintering Apparatus Used for the Formation of Strontium Titanate Bicrystals

Published on: February 9, 2017

10.0K
Fused Filament Fabrication FFF of Metal-Ceramic Components
08:43

Fused Filament Fabrication FFF of Metal-Ceramic Components

Published on: January 11, 2019

17.5K
Bulk and Thin Film Synthesis of Compositionally Variant Entropy-stabilized Oxides
09:41

Bulk and Thin Film Synthesis of Compositionally Variant Entropy-stabilized Oxides

Published on: May 29, 2018

9.7K

Area of Science:

  • Nuclear Medicine
  • Radiochemistry
  • Materials Science

Background:

  • Zirconium-89 (89Zr) is a key radionuclide for positron emission tomography (PET) imaging.
  • The 89Y(p,n)89Zr nuclear reaction is the primary route for 89Zr production using medical cyclotrons.
  • Conventional yttrium targets include electrodeposited, sputtered, powdered, and foil forms.

Purpose of the Study:

  • To investigate Spark Plasma Sintering (SPS) for manufacturing yttrium targets for 89Zr production.
  • To assess the efficiency and yield of 89Zr produced from SPS-manufactured targets.
  • To compare SPS targets with standard yttrium foil targets.

Main Methods:

  • Yttrium discs were manufactured using SPS and bonded to niobium backing plates.
  • Targets were irradiated with a 12 MeV proton beam at 50 μA in a TR19 cyclotron.
  • An automated dissolution module was used for 89Zr purification and recovery.
  • Production yield and recovery efficiency were measured and compared to foil targets.

Main Results:

  • SPS targets withstood high heat power density (650 W·cm-2) for extended irradiation (5 h) without damage.
  • A saturation yield of 14.12 ± 0.38 MBq/μAh was achieved.
  • 89Zr production yield and quality were comparable to those from standard yttrium foil targets.

Conclusions:

  • Spark Plasma Sintering (SPS) is a viable technique for manufacturing yttrium targets for efficient 89Zr radioisotope production.
  • SPS offers a promising manufacturing solution for high-yield 89Zr production.
  • This study validates SPS as a suitable method for advanced nuclear medicine applications.