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Related Experiment Video

Updated: Oct 11, 2025

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Multivariate associative patterns between the gut microbiota and large-scale brain network connectivity.

N Kohn1,2, J Szopinska-Tokov3,4, A Llera Arenas1,2

  • 1Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.

Gut Microbes
|December 3, 2021
PubMed
Summary

This study reveals new links between gut bacteria and brain networks. Specific microbes like Prevotella and Bifidobacterium are associated with brain connectivity patterns in healthy women.

Keywords:
BifidobacteriumLinked ICAPrevotellabrain connectivity networksfMRIgut microbiotaresting state

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Area of Science:

  • Neuroscience
  • Microbiology
  • Systems Biology

Background:

  • The gut-brain axis is crucial for human health, influencing brain function and behavior.
  • Integrating gut microbiome and brain data is challenging due to a lack of multivariate analytical approaches.
  • Understanding these complex interactions is vital for advancing neuroscience and personalized medicine.

Purpose of the Study:

  • To develop and apply an integrative multivariate approach for analyzing gut microbiota and brain connectivity data simultaneously.
  • To identify specific associations between microbial composition and large-scale brain networks in healthy individuals.
  • To explore the complex interplay within the gut-brain axis using novel analytical methods.

Main Methods:

  • Utilized linked independent component analysis (LICA) to analyze data from 58 healthy females.
  • Acquired resting-state functional magnetic resonance imaging (fMRI) data for brain connectivity assessment.
  • Determined gut microbial composition via 16S rRNA gene sequencing of fecal samples.

Main Results:

  • LICA identified four components with significant microbiota contributions, linking gut microbes to brain networks.
  • The default mode network and frontoparietal attention networks showed strong associations with microbial abundance.
  • Prevotella genus abundance correlated with all analyzed brain networks, while Bifidobacterium linked to the default mode and attention networks.

Conclusions:

  • This study provides the first exploratory evidence of multivariate associative patterns between gut microbiota and brain network connectivity in humans.
  • The findings highlight specific microbial taxa that may influence brain function and connectivity.
  • This research opens new avenues for understanding the gut-brain axis and its implications for neurological health.