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Tumor-related Molecular Regulatory Mechanisms of Long Non-coding RNA RMST: Recent Evidence

Xuhui Chen1, Kai Liu1, Wen Xu1

  • 1College of Medical Science, China Three Gorges University, Yichang 443002, China.

Mini Reviews in Medicinal Chemistry
|December 3, 2021
PubMed
Abstract

Insights

Long non-coding RNA rhabdomyosarcoma 2-associated transcript (RMST) is a key regulator in various cancers. This review explores RMST's functions, mechanisms, and therapeutic potential in tumor development and apoptosis.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Long non-coding RNA rhabdomyosarcoma 2-associated transcript (LncRNA RMST) influences tumor progression, including proliferation and apoptosis.
  • RMST serves as a potential biomarker for early cancer diagnosis and therapeutic strategies.

Purpose of the Study:

  • To review the pathophysiological functions of LncRNA RMST.
  • To elucidate the molecular mechanisms underlying RMST's role in multiple tumors.
  • To explore promising biotherapies targeting RMST.

Main Methods:

  • Systematic literature review of 46 PubMed-published papers.
  • Analysis of molecular mechanisms of RMST in various tumor types.

Main Results:

  • LncRNA RMST is aberrantly expressed in diverse tumors such as thyroid, liver, endometrial, colon, pancreatic, glioma, Wilm's, and breast cancers.
  • RMST regulates biological behaviors of tumor and stem cells via multiple molecular pathways, including DNA methylation and SUMOylation.
  • RMST acts as a mechanism-based player, potentially guiding translation and post-translation modifications.

Conclusions:

  • LncRNA RMST is a tumor-related regulatory mediator with significant implications in cancer.
  • RMST holds potential as an original therapeutic target for cancer occurrence, development, and apoptosis.
Keywords:
DNA methylationLong non-coding RNARMSTSOX2therapeutic targettumor

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