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Related Experiment Videos

[alpha-Amylase standard values in children].

S Zabransky, W Tritschler

    Klinische Padiatrie
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    This study determined normal serum alpha-amylase levels in healthy children aged 3 days to 16 years. Proposed normal ranges for children aged 1-16 years are 20-110 U/L at 25°C and 40-200 U/L at 37°C.

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    Multicenter evaluation of a new capillary blood prothrombin time monitoring system.

    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·1995

    Area of Science:

    • Biochemistry
    • Pediatric Medicine
    • Clinical Chemistry

    Context:

    • Establishing reference ranges for serum alpha-amylase is crucial for pediatric diagnostics.
    • Previous data on pediatric alpha-amylase levels, especially in infants, is limited.
    • Variability in enzyme activity measurements necessitates clear reference value determination.

    Purpose:

    • To determine normal serum alpha-amylase concentrations in a cohort of healthy children.
    • To establish age- and temperature-specific reference ranges for serum alpha-amylase.
    • To investigate the influence of age and sex on serum alpha-amylase levels in children.

    Summary:

    • Serum alpha-amylase was measured in 216 healthy children (3 days to 16 years) using p-nitrophenyl-alpha, D-maltoheptaosid substrate.

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  • Infants (3-353 days) exhibited lower alpha-amylase concentrations (up to 30 U/L at 25°C, 60 U/L at 37°C), though statistical significance was limited by sample size.
  • For children aged 1-16 years (n=186), proposed normal ranges are 20-110 U/L at 25°C and 40-200 U/L at 37°C, independent of sex or age.

    • Impact:

    • Provides essential reference values for pediatric serum alpha-amylase, aiding clinical diagnosis.
    • Highlights age-related differences in enzyme activity during early childhood.
    • Establishes reliable normal ranges for children, improving the accuracy of diagnostic interpretations.