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Updated: Oct 11, 2025

Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
Non-traumatic open globe injuries: presenting characteristics and visual outcomes
Andrew W Gross1,2, James Z Fan1, Margaret L Pfeiffer1,2,3
1Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
Non-traumatic open globe injuries, often caused by perforated ulcers, lead to poor visual outcomes. These injuries have higher enucleation rates and worse final visual acuity compared to traumatic open globe injuries.
Area of Science:
- Ophthalmology
- Trauma Surgery
- Public Health
Background:
- Non-traumatic open globe injuries represent a distinct clinical entity.
- Understanding their characteristics is crucial for effective management and patient outcomes.
Purpose of the Study:
- To delineate the clinical features and visual results of non-traumatic open globe injuries.
- To compare outcomes with those of traumatic open globe injuries.
Main Methods:
- Retrospective chart review of non-traumatic open globe patients at a Level 1 trauma center.
- Data collected included demographics, injury cause, clinical presentation, visual acuity (VA), and enucleation rates.
Main Results:
- Thirty eyes were analyzed, predominantly zone 1 injuries, with perforated corneal ulcers being the most common cause (83%).
- Infection was a major factor (80%), presenting with conjunctival injection and corneal opacification.
- Final visual acuity was poor, with 88% worse than 6/60 (20/200), 35% resulting in no light perception (NLP), and 27% requiring enucleation.
Conclusions:
- Non-traumatic open globe injuries, frequently associated with infectious ulcers, exhibit poorer visual prognoses.
- These injuries demonstrate significantly higher enucleation rates and worse final visual acuity compared to traumatic open globe injuries.
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