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SARS-CoV-2-Associated Cerebrovascular Disease Amid the COVID-19 Pandemic: A Systematic Review

Tao Yu1, Hongquan Wang2, Shuhan Zheng1

  • 1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110004, Liaoning, People's Republic of China.

Infection and Drug Resistance
|December 3, 2021
PubMed

Insights

This review summarizes 167 cerebrovascular events in patients with COVID-19, including strokes and cerebral venous thrombosis. Understanding these SARS-CoV-2-cerebrovascular disease patterns aids clinical anticipation of outcomes.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Increasing reports link SARS-CoV-2 infection to cerebrovascular diseases (CVD).
  • A comprehensive literature analysis of SARS-CoV-2-cerebrovascular disease (SCVD) is needed.
  • This study reviews SCVD, covering clinical features, mechanisms, treatment, and outcomes.

Purpose of the Study:

  • To conduct a retrospective analysis of the existing literature on SCVD.
  • To synthesize information on the clinical presentation, management, and prognosis of SCVD.
  • To provide a foundation for understanding the neurological complications of COVID-19.

Main Methods:

  • Systematic literature search of PubMed for case reports and series on SCVD.
  • Inclusion of studies published between January 1, 2020, and June 20, 2020.
  • Extraction and summarization of demographic and clinical data from 51 articles.

Main Results:

  • A total of 167 cerebrovascular events were reported in patients with confirmed COVID-19.
  • Cerebrovascular events included ischemic stroke, cerebral hemorrhage, subarachnoid hemorrhage, and cerebral venous thrombosis.
  • Detailed patient characteristics were summarized from the included literature.

Conclusions:

  • The summarized patient characteristics can assist clinicians in anticipating SCVD outcomes.
  • This review highlights the significant neurological impact of SARS-CoV-2 infection.
  • Further research is warranted to elucidate the mechanisms and optimize treatment for SCVD.
Abstract

Keywords:
COVID-19cerebral hemorrhagecerebral venous thrombosiscerebrovascular diseasestroke

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