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Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?
Wen Bo Sam Zhou1,2, JingWen Meng1,2, Ji Zhang1,2,3
1The Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Frontiers in Molecular Neuroscience
|December 3, 2021
Summary
Systemic chronic inflammation (SCI) may contribute to the development of chronic pain and related conditions. Further research is needed to understand the complex link between SCI and chronic pain, impacting patient quality of life.
Area of Science:
- Neuroscience
- Immunology
- Pain Medicine
Background:
- Chronic pain, a major manifestation of peripheral neuropathy, significantly impacts quality of life.
- Underlying mechanisms of chronic pain are not fully understood, and treatments are often unsatisfactory.
- Systemic chronic inflammation (SCI) is a persistent, low-grade inflammatory state linked to various chronic diseases.
Purpose of the Study:
- To explore the potential role of Systemic Chronic Inflammation (SCI) as a factor in chronic pain development.
- To review existing evidence on the association between SCI and chronic pain.
- To highlight the need for further investigation into the SCI-chronic pain connection.
Main Methods:
- Review of human clinical studies examining the coexistence of SCI and chronic pain.
- Collated data on the sources and prevalence of SCI.
- Analysis of existing literature on the relationship between SCI, chronic pain, and comorbidities.
Main Results:
- Evidence indicates a coexistence of SCI with various types of chronic pain.
- Individuals with SCI show a higher prevalence of chronic pain and psychological comorbidities.
- SCI may be a predisposing or precipitating factor in chronic pain development.
Conclusions:
- Systemic chronic inflammation is potentially linked to the development of chronic pain.
- Further research is crucial to elucidate the complex interactions between SCI and chronic pain.
- Understanding this link may lead to improved therapeutic strategies for chronic pain management.
Keywords:
chemokineschronic paincytokinesperipheral neuropathypsychological disorderssystemic chronic inflammationsystemic modulationMore Related Videos
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