Related Experiment Video

Updated: Oct 11, 2025

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
08:35

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

Published on: January 4, 2012

28.4K

The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer

Ghazal Mohseni1,2, Juan Li1, Abakundana Nsenga Ariston Gabriel1,2

  • 1Department of Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Frontiers in Immunology
|December 3, 2021
PubMed

Insights

Stimulator of interferon genes (STING) pathway activation shows promise for cancer immunotherapy, particularly in pancreatic cancer. This review explores STING

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • The stimulator of interferon genes (STING) pathway is crucial for detecting cytosolic DNA and initiating immune responses.
  • STING activation links innate and adaptive immunity, influencing the tumor microenvironment (TME).
  • Pancreatic cancer exhibits a highly immunosuppressive TME, posing challenges for effective treatment.

Purpose of the Study:

  • To review the role of STING signaling in pancreatic cancer and related diseases.
  • To discuss advancements in STING-based monotherapy and combination strategies for pancreatic cancer immunotherapy.

Main Methods:

  • Literature review of STING pathway activation and its role in cancer.
  • Analysis of STING's impact on immune cells within the pancreatic TME.
  • Synthesis of current research on STING as a therapeutic target in pancreatic cancer.

Main Results:

  • STING pathway activation can enhance anti-tumor immune responses.
  • STING plays a significant role in modulating the immunosuppressive TME of pancreatic cancer.
  • Emerging evidence supports STING-based therapies for pancreatic cancer.

Conclusions:

  • STING signaling is a promising target for pancreatic cancer immunotherapy.
  • Novel therapeutic strategies involving STING are being developed for pancreatic cancer treatment.
  • Further research into STING modulation could overcome treatment resistance in pancreatic cancer.
Keywords:
cGAS-STING pathwaycytosolic DNAimmunotherapypancreatic cancertype I interferon (IFN)

More Related Videos

Author Spotlight: Validating Cancer Therapy Responses with Desmoplastic Spheroid Models03:42

Author Spotlight: Validating Cancer Therapy Responses with Desmoplastic Spheroid Models

Published on: September 27, 2024

1.6K
An Orthotopic Resectional Mouse Model of Pancreatic Cancer07:17

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

11.1K

Related Concept Videos

GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
6.1K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
140
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.9K