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Biological function and molecular mechanism of SRSF3 in cancer and beyond

Jian Xiong1, Yinshuang Chen2, Weipeng Wang2

  • 1Institute of Medical Biotechnology, Suzhou Vocational Health College, Suzhou, Jiangsu 215009, P.R. China.

Oncology Letters
|December 3, 2021
PubMed

Insights

Serine/arginine-rich splicing factor 3 (SRSF3) is abnormally expressed in tumors, driving cancer progression. Inhibiting SRSF3 suppresses tumor cell proliferation and metastasis, suggesting it as a potential anti-tumor target.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Gene Regulation

Background:

  • Serine/arginine-rich splicing factor 3 (SRSF3), also known as SRp20, is a key splicing factor.
  • SRSF3 expression and splicing are tightly regulated under normal physiological conditions.
  • Aberrant SRSF3 expression is observed in various tumors.

Purpose of the Study:

  • To review the biological functions of SRSF3 in cancer.
  • To explore the regulatory mechanisms of SRSF3.
  • To evaluate SRSF3 as a potential anti-tumor therapeutic target.

Main Methods:

  • Literature review of studies on SRSF3 in cancer.
  • Analysis of SRSF3's role in splicing of key cancer-related genes (e.g., CD44, HER2, MDM4, p53).
  • Examination of SRSF3's impact on tumor cell proliferation, cell cycle, metastasis, senescence, apoptosis, and autophagy.

Main Results:

  • SRSF3 dysregulation contributes to aberrant splicing of critical genes in tumors.
  • SRSF3 promotes tumorigenesis, proliferation, cell cycle progression, and metastasis.
  • SRSF3 inhibits cell senescence, apoptosis, and autophagy.
  • SRSF3 knockdown significantly impairs tumor cell proliferation and metastasis.

Conclusions:

  • SRSF3 plays a multifaceted role in cancer development and progression.
  • Dysregulated SRSF3 impacts multiple hallmarks of cancer.
  • SRSF3 represents a promising novel target for anti-cancer therapies.
Keywords:
RNA transportSRSF3oncogenepost-transcriptional regulationsplicing

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