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Related Concept Videos

Brain Imaging01:14

Brain Imaging

382
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
382
Positron Emission Tomography01:29

Positron Emission Tomography

6.1K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.1K

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Related Experiment Video

Updated: Oct 11, 2025

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
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PET-CT in brain disorders: The South African context.

Alexander G G Doruyter1,2, Jeannette Parkes3, Jonathan Carr4

  • 1NuMeRI Node for Infection Imaging, Central Analytical Facilities, Stellenbosch University, Cape Town, South Africa.

SA Journal of Radiology
|December 3, 2021
PubMed
Summary

Positron emission tomography (PET-CT) is valuable for brain disorders but underutilized in South Africa due to limited facilities and guidelines. This review details its evidence-based use in conditions like dementia and brain tumors.

Keywords:
F-18 fluoro-dihydroxyphenylalanineF-18 fluorodeoxyglucoseParkinson’s diseasebrainbrain tumourdementiapositron emission tomography

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Area of Science:

  • Neurology
  • Nuclear Medicine
  • Radiology

Background:

  • Positron emission tomography combined with X-ray computed tomography (PET-CT) is a powerful diagnostic tool for brain disorders.
  • Its utilization in South Africa is potentially limited by facility availability and a lack of specific clinical guidelines.
  • Understanding the evidence-based applications is crucial for appropriate implementation.

Purpose of the Study:

  • To review the established clinical applications of brain PET-CT in various neurological conditions.
  • To identify areas where PET-CT has a current research role but no clinical utility.
  • To discuss strategies for improving the appropriate use of PET-CT in South Africa.

Main Methods:

  • Literature review of evidence-based applications of brain PET-CT.
  • Analysis of current utilization barriers in South Africa.
  • Discussion of future implementation strategies.

Main Results:

  • PET-CT has established roles in dementia, movement disorders, brain tumors, epilepsy, neuropsychiatric lupus, immune-mediated encephalitides, and brain infections.
  • PET-CT is currently a research tool, not clinically indicated, for traumatic brain injury, psychiatric, and neurodevelopmental disorders.
  • Barriers to access in South Africa include limited facilities and lack of contemporary guidelines.

Conclusions:

  • Brain PET-CT offers significant diagnostic value across a range of neurological conditions.
  • Clearer guidelines and increased accessibility are needed to optimize PET-CT use in South Africa.
  • Strategic expansion can enhance patient care for brain disorders through appropriate PET-CT utilization.