Related Experiment Video
Updated: Oct 11, 2025
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Barriers and Proposed Solutions to a Successful Implementation of Pediatric Sepsis Protocols
Daniela Nasu Monteiro Medeiros1, Audrey Ogawa Shibata1, Cristiane Freitas Pizarro1
1Pediatric Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Insights
Implementing pediatric sepsis protocols improves patient outcomes by reducing treatment times and mortality. However, barriers like resource limitations and varying causes of sepsis in low-middle-income countries require tailored approaches for effective sepsis management.
Area of Science:
- Pediatrics
- Infectious Diseases
- Critical Care Medicine
Background:
- Managed protocols standardize patient care and outcomes evaluation.
- Pediatric sepsis protocols offer advantages like reduced treatment delays and improved survival rates.
- Barriers to protocol implementation include lack of resources, healthcare professional engagement, and parental awareness.
Purpose of the Study:
- To evaluate the impact of pediatric sepsis recognition and treatment protocols.
- To identify advantages and barriers associated with protocol implementation.
- To address challenges specific to low-middle-income countries (LMIC).
Main Methods:
- Systematic review and analysis of existing literature on sepsis protocols.
- Comparison of protocol effectiveness in high-income versus low-middle-income countries.
- Assessment of factors influencing protocol success, including disease prevalence and resource availability.
Main Results:
- Protocols can decrease time to fluid and antibiotic administration, reduce organ dysfunction, and lower mortality.
- Barriers include absence of written protocols, diagnostic challenges, and limited drug availability.
- Adaptation of protocols is crucial in LMIC due to different prevalent pathogens (e.g., dengue, malaria) and resource constraints.
Conclusions:
- Sepsis protocols should be simple, precise, and supported by education.
- Effective communication and teamwork among healthcare professionals are vital.
- Celebrating results and adapting protocols to local contexts enhance their impact on patient outcomes.
Abstract:
The implementation of managed protocols contributes to a systematized approach to the patient and continuous evaluation of results, focusing on improving clinical practice, early diagnosis, treatment, and outcomes. Advantages to the adoption of a pediatric sepsis recognition and treatment protocol include: a reduction in time to start fluid and antibiotic administration, decreased kidney dysfunction and organ dysfunction, reduction in length of stay, and even a decrease on mortality. Barriers are: absence of a written protocol, parental knowledge, early diagnosis by healthcare professionals, venous access, availability of antimicrobials and vasoactive drugs, conditions of work, engagement of healthcare professionals. There are challenges in low-middle-income countries (LMIC). The causes of sepsis and resources differ from high-income countries. Viral agent such as dengue, malaria are common in LMIC and initial approach differ from bacterial infections. Some authors found increased or no impact in mortality or increased length of stay associated with the implementation of the SCC sepsis bundle which reinforces the importance of adapting it to most frequent diseases, disposable resources, and characteristics of healthcare professionals. Conclusions: (1) be simple; (2) be precise; (3) education; (5) improve communication; (5) work as a team; (6) share and celebrate results.
Related Concept Videos
01:22Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
01:26Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
01:21Barriers to Effective Communication II
Cultural barriers:
Differences in values, beliefs, religion, knowledge, and tradition can significantly impact communication. Awareness of nonverbal cues is critical, especially when conversing with a patient from a different culture. What appears appropriate in one culture may be inappropriate in another.
Semantic barriers:
As a result of their tendency to use...
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
01:28Asepsis