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Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
Joel D Pearson1,2,3, Rod Bremner1,2,3
1Lunenfeld Tanenbaum Research Institute, Mt Sinai Hospital, Sinai Health System, Toronto, Canada.
Molecular & Cellular Oncology
|December 3, 2021
Summary
Cancer treatment is complex. A single transcriptional complex's opposite expression and activity stratifies cancer into two binary superclasses, offering broadly applicable treatment strategies.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Genomics
Background:
- Cancer's complexity presents significant challenges for developing effective treatments.
- Identifying fundamental principles in cancer biology is crucial for discovering universal therapeutic strategies.
Purpose of the Study:
- To investigate higher-order principles governing cancer biology.
- To determine if a single transcriptional complex can stratify cancers into functional classes.
Main Methods:
- Analysis of gene expression patterns.
- Functional assays of transcriptional complex activity.
- Cancer stratification based on molecular and functional data.
Main Results:
- A single transcriptional complex exhibits opposite expression patterns in different cancer types.
- The pro- or anti-cancer activity of this complex correlates with distinct cancer stratifications.
- Cancers were functionally stratified into binary superclasses based on this complex.
Conclusions:
- The identified transcriptional complex serves as a key functional stratifier for diverse cancers.
- This discovery provides a higher-order principle to simplify cancer classification.
- Targeting this complex may offer broadly applicable therapeutic strategies across cancer superclasses.
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