Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Overlap connective tissue syndromes.

R C Allen, C St-Cyr, P J Maddison

    Archives of Disease in Childhood
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Rhinological manifestations of Sjögren's syndrome: a cohort-matched, prospective, cross-sectional, observational study.

    The Journal of laryngology and otology·2021
    Same author

    SCIg vs. IVIg: let's give patients the choice!

    Journal of clinical immunology·2014
    Same author

    Still's Disease Followed into Adult Life.

    Proceedings of the Royal Society of Medicine·2010
    Same author

    Prevention of vascular damage in scleroderma and autoimmune Raynaud's phenomenon: a multicenter, randomized, double-blind, placebo-controlled trial of the angiotensin-converting enzyme inhibitor quinapril.

    Arthritis and rheumatism·2007
    Same author

    Intra-articular methotrexate in knee synovitis.

    Rheumatology (Oxford, England)·2004
    Same author

    Sarcoidosis in the pediatric age.

    Clinical and experimental rheumatology·2002
    Same journal

    Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study.

    Archives of disease in childhood·2026
    Same journal

    Artificial intelligence for child health: current capabilities and the next frontier.

    Archives of disease in childhood·2026
    Same journal

    Troubled origins and lasting impact of the first insulin injection.

    Archives of disease in childhood·2026
    Same journal

    Paediatric readiness assessment tools in emergency care: a scoping review.

    Archives of disease in childhood·2026
    Same journal

    Building a paediatric workforce to deliver the NHS prevention agenda: time for paediatric public health medicine?

    Archives of disease in childhood·2026
    Same journal

    Impact of antenatal biological response modifying drugs on infant infection risk and vaccination rates: a national cohort study.

    Archives of disease in childhood·2026
    See all related articles

    This study investigated children with overlapping connective tissue disorder features. Many presented with arthritis and rashes, but few developed severe systemic disease or met criteria for mixed connective tissue disease.

    Area of Science:

    • Pediatric Rheumatology
    • Connective Tissue Diseases
    • Autoimmune Disorders

    Background:

    • Children presenting with overlapping features of multiple connective tissue disorders pose diagnostic challenges.
    • Understanding the natural history and clinical spectrum of these overlapping conditions is crucial for effective management.

    Purpose of the Study:

    • To describe the clinical presentation, follow-up course, and diagnostic criteria fulfillment in a cohort of children with overlapping connective tissue disorder features.
    • To investigate the utility of antibody profiles in differentiating clinical patterns in this pediatric population.

    Main Methods:

    • Retrospective case series of 26 children with overlapping connective tissue disorder features.
    • Data collection included presenting symptoms, clinical findings at follow-up, and serological markers, including antibodies to nuclear ribonucleoprotein.

    Related Experiment Videos

  • Assessment of diagnostic criteria for mixed connective tissue disease.

    • Main Results:

    • The median age of onset was 9.5 years, with a median follow-up of 7.5 years.
    • Common initial symptoms included arthritis, tenosynovitis, Raynaud's phenomenon, myositis, and rashes.
    • Sclerodermatous skin changes developed in 14 patients, but significant systemic involvement was infrequent.
    • Only 16 of 26 patients met the criteria for mixed connective tissue disease, with no clear differentiation of clinical patterns based on antibody profiles.

    Conclusions:

    • Children with overlapping connective tissue disorder features often present with musculoskeletal and mucocutaneous symptoms.
    • A significant proportion of these children do not meet the diagnostic criteria for mixed connective tissue disease, highlighting the heterogeneity of these conditions.
    • Clinical presentation and antibody profiles alone were insufficient to differentiate distinct clinical patterns in this cohort.