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Updated: Oct 11, 2025
09:10
siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
Published on: October 28, 2019
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Autophagy and antiviral defense
Po-Yuan Ke1,2
1Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
IUBMB Life
|December 3, 2021
Summary
Autophagy, a cellular process, plays a dual role in viral infections by aiding viral replication and modulating the host
Area of Science:
- Cellular Biology
- Immunology
- Virology
Background:
- Autophagy maintains cellular homeostasis and combats pathogens.
- Viruses often induce autophagy to promote their replication and modulate host antiviral immunity.
Purpose of the Study:
- To describe mechanisms of autophagy and innate antiviral response.
- To review autophagy's role in antiviral defense against various viruses.
- To discuss the impact of autophagy on viral life cycles and signaling.
Main Methods:
- Literature review of autophagy and antiviral immunity.
- Analysis of virus-induced autophagy mechanisms.
- Synthesis of current research on autophagy's role in viral infections.
Main Results:
- Autophagy has diverse roles in controlling viral infections.
- Virus-induced autophagy impacts host defense and viral replication.
- Autophagy regulates the balance between viruses and host cells.
Conclusions:
- Autophagy is a critical regulator of the innate antiviral immune response.
- Understanding virus-autophagy interactions is key to developing antiviral strategies.
- Autophagy modulation offers potential therapeutic avenues against viral diseases.
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