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Related Experiment Video

Updated: Oct 11, 2025

TiO2-coated Hollow Glass Microspheres with Superhydrophobic and High IR-reflective Properties Synthesized by a Soft-chemistry Method
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Titanium-Containing Silicate-Based Sol-Gel Bioactive Glass: Development, Characterization, and Applications.

Sophia Smith1, Osama ElKashty2,3, Faleh Tamimi2

  • 1Department of Mining and Materials Engineering, McGill University, Montreal, Quebec H3A 2T5, Canada.

Langmuir : the ACS Journal of Surfaces and Colloids
|December 3, 2021
PubMed
Summary
This summary is machine-generated.

Titanium-doped bioactive glass forms titanium-substituted hydroxyapatite in simulated body fluid. This material enhances dental enamel microhardness and promotes bone cell differentiation, showing promise for dental and bone tissue engineering applications.

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Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Biomineralization

Background:

  • Bioactive glasses react with physiological fluids to form hydroxyapatite.
  • Doping bioactive glasses with ions like titanium can enhance their properties.
  • Titanium in dental enamel correlates with increased tooth hardness and brightness.

Purpose of the Study:

  • To synthesize a titanium-containing silicate-based bioactive glass using the sol-gel method.
  • To investigate the formation of titanium-substituted hydroxyapatite upon immersion in simulated body fluid.
  • To evaluate the potential of this material for dental enamel remineralization and bone tissue engineering.

Main Methods:

  • Sol-gel synthesis of titanium-containing silicate-based bioactive glass.
  • Immersion of the synthesized glass in simulated body fluid for 14 days.
  • Characterization of the surface transformation and evaluation of enamel microhardness and cell differentiation.

Main Results:

  • Homogeneous distribution of titanium within the amorphous glass structure.
  • Formation of a titanium-substituted hydroxyapatite layer on the glass surface after immersion.
  • Significant increase in microhardness of enamel surfaces treated with titanium-containing glass.
  • Promotion of cell differentiation towards bone formation by the titanium-doped glass.

Conclusions:

  • The synthesized titanium-containing bioactive glass effectively forms titanium-substituted hydroxyapatite in simulated body fluid.
  • The material demonstrates potential for enhancing dental enamel microhardness, indicating applications in remineralization.
  • The glass promotes osteogenic differentiation, suggesting utility in bone tissue engineering.