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Updated: Oct 11, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
A Tale of Unequal Substitution: Minocycline and Acute Autoimmune Hepatitis
Dana H Manning1, Emily DeBuck1, Mallory Simchick1
1Wilkes University, Wilkes-Barre, PA, USA.
Abstract:
Objective: In this case report, we describe the development of an acute autoimmune hepatitis associated with a short course of minocycline prescribed for a skin infection. Due to a drug shortage, minocycline was substituted for doxycycline. Conclusions: It is imperative that practitioners be aware of the different risks that accompany switching between drugs in the tetracycline class, particularly the risk of autoimmune conditions including hepatitis.
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