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Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic
Eelco J P de Koning1, Françoise Carlotti2
1Department of Internal Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, the Netherlands; Transplantation Center, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, the Netherlands.
Abstract:
One hundred years after the discovery of insulin, Kieffer and colleagues (Ramzy et al., 2021) and Foyt and colleagues (Shapiro et al., 2021) report interim results from a multicenter clinical trial showing insulin secretion from engrafted pluripotent stem cell-derived endocrine progenitor cells in patients with type 1 diabetes.
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