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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
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Antihistamines for cancer immunotherapy: More than just treating allergies
1Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Abstract:
In this issue of Cancer Cell, Li et al. show that histamine released in allergic reactions and from tumor cells attenuates immunotherapy response. Histamine H1-receptor (H1R) signaling induces an M2-like phenotype in tumor-associated macrophages and increases VISTA expression, suppressing CD8+ T cell function. Antihistamines reverse these effects and improve the efficacy of immunotherapy.
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