Related Experiment Video
Updated: Oct 11, 2025
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
Study on collateral circulation level and prognosis of acute ischemic stroke by 4D CTA-CTP integrated technology and
Gang Peng1, Weiping Lu2, Kai Chen2
1Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Objective:
To evaluate the cerebral collateral circulation in patients with acute ischemic stroke (AIS) by Four-dimensional CT angiography-CT perfusion (4D CTA-CTP)-integrated technology, and to explore the feasibility of predicting the prognosis of patients with AIS by using cerebral collateral circulation and serum S100B protein concentration.
Methods:
Thirty-two patients with anterior circulation AIS who underwent 4D CTA-CTP were retrospectively analysed. The level of cerebral collateral circulation was assessed by multi-phase CT angiography (mCTA) scores and regional leptomeningeal collateral (rLMC) scores. Combined with serum S100B protein concentration, multivariate binary logistic regression was used to explore the indicators that can independently predict the prognosis of AIS neurological function.
Results:
Univariate analysis showed that the baseline National Institutes of Health stroke scale score, rLMC score, and mCTA score were correlated with the neurological prognosis of patients with AIS; multivariate analysis showed that mCTA cerebral collateral circulation score was the only indicator that could independently predict the neurological prognosis of AIS patients (OR = 0.065, P = 0.030). The baseline serum S100B protein concentration could not independently predict the neurological prognosis of AIS patients.
Conclusion:
mCTA cerebral collateral circulation scores can independently predict the neurological prognosis of patients with AIS. For the assessment of neurological prognosis of AIS patients, the cerebral collateral circulation phase score is better than the regional score.
