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Spatial mapping of cancer tissues by OMICS technologies
Rashid Ahmed1, Robin Augustine2, Enrique Valera3
1Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha 2713, Qatar; Biomedical Research Center (BRC), Qatar University, Doha 2713, Qatar; Nick Holonyak Jr. Micro and Nanotechnology Laboratory, University of Illinois at Urbana Champaign, IL, USA.
Biochimica Et Biophysica Acta. Reviews on Cancer
|December 3, 2021
Summary
Spatial mapping of gene expression in cancer tissues using OMICS technologies aids cancer understanding and detection. Further advancements are needed for widespread clinical and research applications of these high-throughput spatial profiling methods.
Area of Science:
- Oncology
- Genomics
- Biotechnology
Background:
- Spatial mapping of gene expression heterogeneity in cancer tissues is crucial for improved understanding and early detection.
- Recent advancements in OMICS technologies offer potential for single-cell level spatial profiling of biopsy samples.
Purpose of the Study:
- To review recent advancements and prospects of OMICS technologies for spatial mapping of analytes in cancer tissues.
- To benchmark the current state-of-the-art in high-throughput spatial profiling.
Main Methods:
- Review of recent literature on OMICS technologies for spatial profiling in cancer.
- Benchmarking of current technologies based on spatial resolution, biomolecule types, multiplexing capability, detection methods (labeled vs. label-free), and assay time.
Main Results:
- OMICS technologies show strong potential for spatial mapping and molecular profiling of cancer tissues at a single-cell level.
- Clinical applications of OMICS in spatial profiling are advancing, with ongoing development in high-throughput methods.
Conclusions:
- Further advancements in OMICS technologies are required for widespread adoption in fast, high-throughput spatial mapping of cancer tissues.
- Effective integration of these technologies into research and clinical practice necessitates continued innovation and development.