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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Related Experiment Video

Updated: Oct 11, 2025

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

Introduction: Progress Towards Genomically-directed Radiosensitization.

Gaorav P Gupta¹, Ranjit S Bindra²

¹Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC.

Seminars in Radiation Oncology

|December 4, 2021

Summary

This summary is machine-generated.

Radiation therapy uses advanced technology for precise treatment. Targeting specific tumor genetic, epigenetic, and metabolic changes can overcome radiation resistance, improving cancer treatment outcomes.

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Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Area of Science:

Oncology
Radiation Oncology
Molecular Biology

Background:

Radiation therapy offers precise ionizing radiation delivery but faces challenges with intrinsic tumor resistance.
Tumor resistance to radiotherapy can lead to incomplete tumor eradication and limited symptom palliation.

Discussion:

Radiation resistance is often linked to alterations in genetic, epigenetic, and metabolic pathways within tumors.
Targeting these specific tumor alterations offers a strategy for radiosensitization.

Key Insights:

Genomically-directed radiosensitization aims to enhance radiation therapy effectiveness.
Therapeutic targeting can achieve tumor-selective radiosensitization while sparing normal tissues.

Outlook:

Future research focuses on exploiting tumor-specific vulnerabilities for improved radiotherapy outcomes.
Advancements in understanding resistance mechanisms pave the way for novel radiosensitizing strategies.