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Study on the clinical effects of targeted therapy on elderly patients with gastric cancer

Lifei Gao1, Wei Li1, Yagang Liu1

  • 1Department of General Surgery, Cangzhou Central Hospital, Cangzhou, China.

Pakistan Journal of Pharmaceutical Sciences
|December 4, 2021
PubMed

Insights

Targeted drug therapies, including bevacizumab and apatinib, show significant clinical benefits for elderly gastric cancer patients. These treatments effectively inhibit tumor growth and reduce complications, demonstrating their value in clinical practice.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Gastric cancer poses a significant health challenge, particularly in elderly populations.
  • Metastatic gastric cancer requires effective therapeutic strategies to improve patient outcomes.

Purpose of the Study:

  • To evaluate the clinical efficacy of targeted drug therapies in elderly patients with metastatic gastric cancer.
  • To compare the effects of bevacizumab, apatinib, and recombinant human endostatin against standard care.

Main Methods:

  • A randomized controlled trial involving 200 elderly metastatic gastric cancer patients.
  • Patients were divided into four groups: bevacizumab, apatinib, recombinant human endostatin, and a control group.
  • Clinical data, therapeutic effects, and biomarker levels (VEGF, sVEGFR2, HER2) were analyzed.

Main Results:

  • Targeted drug groups showed significantly better positive detection rates for VEGF, sVEGFR2, and HER2 compared to the control group (P<0.05).
  • Therapeutic effects were higher in groups receiving targeted drugs.
  • The incidence of adverse reactions was lower in the targeted drug groups (P<0.05).

Conclusions:

  • Targeted drug therapies demonstrate significant clinical effectiveness in treating elderly patients with gastric cancer.
  • These agents can effectively inhibit tumor progression and decrease complication rates.
  • Bevacizumab, apatinib, and recombinant human endostatin are recommended for broader clinical application in gastric cancer treatment.

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