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The Raise of Neurodevelopmental Disorders (NDS): From Genetics to Epigenetics
1ECERI European Cancer and Environment Research Institute, Bruxelles, Belgium, erburg@libero.it.
Psychiatria Danubina
|December 4, 2021
Summary
Neurodevelopmental disorders (NDs) involve early developmental issues impacting cognition and behavior. Both genetic and environmental factors, including epigenetics, contribute to their increasing prevalence.
Area of Science:
- Neuroscience
- Developmental Biology
- Genetics
Background:
- Neurodevelopmental disorders (NDs) manifest early in life, causing cognitive and behavioral impairments.
- Conditions like autism and schizophrenia exhibit high heritability, suggesting a strong genetic basis.
- A significant rise in ND prevalence points to crucial roles for environmental influences and epigenetic mechanisms.
Purpose of the Study:
- To explore the complex etiology of neurodevelopmental disorders.
- To investigate the interplay between genetic predisposition and environmental factors in ND development.
Main Methods:
- Review of existing literature on neurodevelopmental disorders.
- Analysis of genetic and environmental contributions to NDs.
- Examination of epigenetic mechanisms in developmental conditions.
Main Results:
- Heritability is a significant factor in specific NDs, such as autism and schizophrenia.
- Environmental factors and epigenetic modifications are increasingly implicated in the rising incidence of NDs.
- A multifactorial model is necessary to understand ND origins.
Conclusions:
- Neurodevelopmental disorders result from a complex interaction of genetic and environmental factors.
- Epigenetic mechanisms represent a key area for understanding environmental influences on NDs.
- Further research is needed to elucidate the precise interplay of these factors in NDs.
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