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Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration:
Jie Cao1, Lusen Ran1, Chenchen Liu1
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
BMC Neurology
|December 5, 2021
Summary
Subacute combined degeneration (SCD) linked to nitrous oxide abuse can cause neurological issues. This study reveals decreased serum copper and cerebellar atrophy as potential new diagnostic markers for SCD.
Area of Science:
- Neurology
- Toxicology
Background:
- Subacute combined degeneration (SCD) is a neurological disorder often linked to vitamin B12 deficiency.
- Nitrous oxide (N2O) abuse is an emerging cause of SCD, leading to neuropsychiatric symptoms.
Observation:
- This report details two young patients with SCD resulting from N2O abuse.
- Both patients presented with elevated homocysteine, macrocytic anemia, spinal cord, and peripheral nerve damage.
Findings:
- For the first time, decreased serum copper levels and cerebellar atrophy were observed in these SCD patients.
- These neurological and biochemical alterations were noted alongside typical SCD indicators.
Implications:
- The findings suggest serum copper levels and cerebellar appearance may serve as novel diagnostic indicators for SCD.
- Early identification of these markers could aid in managing N2O-induced neurological complications.
