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METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children.

Zhenjian Zhuo1, Rui-Xi Hua1, Huizhu Zhang2

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|December 5, 2021
PubMed
Summary
This summary is machine-generated.

Genetic variants in the METTL14 gene, specifically rs1064034 and rs298982, are associated with reduced Wilms tumor risk. These findings suggest METTL14 single nucleotide polymorphisms (SNPs) may influence Wilms tumor development.

Keywords:
Case-control studyMETTL14PolymorphismRiskWilms tumor

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Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Wilms tumor is a highly heritable childhood kidney cancer.
  • Aberrant METTL14, involved in N6-methyladenosine (m6A) modification, is implicated in cancer.
  • The role of METTL14 genetic variants in Wilms tumor susceptibility requires further investigation.

Purpose of the Study:

  • To investigate the association between genetic variants in the METTL14 gene and Wilms tumor susceptibility.
  • To identify specific single nucleotide polymorphisms (SNPs) within METTL14 that may confer risk or protection.

Main Methods:

  • Genotyping of 403 Wilms tumor patients and 1198 controls using TaqMan assay.
  • Analysis of five single nucleotide polymorphisms (SNPs) in the METTL14 gene.
  • Haplotype and stratified analyses were performed to validate findings.

Main Results:

  • Two SNPs, rs1064034 T>A and rs298982 G>A, showed a significant association with decreased Wilms tumor susceptibility.
  • A combination of five protective genotypes demonstrated a stronger protective effect (OR=0.69).
  • These SNPs correlate with the expression and splicing of nearby genes, suggesting a functional link.

Conclusions:

  • Single nucleotide polymorphisms (SNPs) in the METTL14 gene may act as genetic modifiers in the development of Wilms tumor.
  • Specific METTL14 variants confer a protective effect against Wilms tumor.
  • Further research into METTL14's role in Wilms tumor pathogenesis is warranted.