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Updated: Oct 11, 2025

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
Published on: January 6, 2014
MDSCs sneak CSCs out of (immuno)surveillance
Carlos Jiménez-Cortegana1, Claudia Galassi2, Lorenzo Galluzzi3
1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Department of Medical Biochemistry, Molecular Biology, and Immunology, Faculty of Medicine, University of Seville, Seville, Spain; Clinical Biochemistry, Virgen Macarena University Hospital, Seville, Spain.
Abstract:
Cancer stem cells (CSCs) are known for their superior tumor-initiating and tumor-repopulating potential, partly reflecting their pronounced ability to evade immune recognition. Liu and colleagues recently identified a new aldehyde dehydrogenase (ALDH)-dependent mechanism whereby triple-negative breast CSCs evade immunosurveillance upon recruitment of myeloid-derived suppressor cells.
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