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Epoxylipids and soluble epoxide hydrolase in heart diseases

John D Imig1, Ludek Cervenka2, Jan Neckar3

  • 1Drug Discovery Center and Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA.

Biochemical Pharmacology
|December 5, 2021
PubMed

Insights

Epoxylipids, regulated by soluble epoxide hydrolase (sEH), show therapeutic potential for heart diseases. Increasing these fatty acids can improve cardiac function and treat conditions like arrhythmias and heart failure.

Area of Science:

  • Cardiovascular biology
  • Biochemistry
  • Pharmacology

Background:

  • Cardiovascular diseases are major causes of death, driven by endothelial dysfunction, inflammation, and mitochondrial issues.
  • Fatty acid epoxylipids and their regulation by soluble epoxide hydrolase (sEH) are implicated in heart disease progression.
  • Genetic and pharmacological studies show epoxylipid manipulation offers therapeutic benefits for cardiac conditions.

Purpose of the Study:

  • To review the role of epoxylipids in cardiovascular and heart diseases.
  • To explore the therapeutic potential of manipulating epoxylipid levels for treating heart conditions.

Main Methods:

  • Literature review of past and recent findings on epoxylipids and heart disease.
  • Analysis of studies involving genetic and pharmacological manipulation of epoxylipids.

Main Results:

  • Elevated epoxylipids reduce cardiac hypertrophy, fibrosis, and improve overall cardiac function.
  • Epoxylipids demonstrate beneficial effects in ischemia reperfusion injury, arrhythmias, and ventricular tachycardia.

Conclusions:

  • Epoxylipids play a significant role in the pathophysiology of heart diseases.
  • Targeting epoxylipid pathways presents a promising therapeutic strategy for heart attacks, arrhythmias, and heart failure.

Keywords:
Coronary arteryCytochrome P450EicosanoidsHeart failureHypertensionInflammationMitochondrial functionMyocardial infarctionSoluble epoxide hydrolase

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