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Updated: Oct 11, 2025

Generation and Characterization of Human Induced Pluripotent Stem Cell-derived Astrocytes Lacking Fragile X Messenger Ribonucleoprotein
Published on: June 6, 2025
Derivation of iPS cell line (ICGi032-A) from a patient affected with fragile X syndrome
M M Gridina1, E M Shitik2, N A Lemskaya3
1Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia.
Abstract:
Trinucleotide repeat expansion diseases such as fragile X syndrome are of great interest to study since the mechanism of its development is still unknown. IPS cell lines are some of the most convenient models for studying. The ICGi032-A iPS cell line was obtained from the peripheral blood mononuclear cells of the patient affected with fragile X syndrome. ICGi032-A iPS cell line have a normal karyotype, expression of pluripotency markers and can differentiate in vitro into the cells of three germ layers.
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